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To answer this question, we first have to understand what causes high cholesterol in the first place. This condition actually possess many causes including family history, body weight, diet, physical activity, sleep deprivation, kidney disease, diabetes, hypothyroidism, Cushing’s syndrome, Anorexia Nervosa, Zieve’s syndrome and even certain drug use. Family history alone can be enough to cause this problem when not one other factors are mixed together.